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The language "tetracycline compound responsive state" or "tetracycline responsive state" includes states which can be treated, prevented, or otherwise ameliorated by the administration of a tetracycline compound of the invention, eg, a 4-dedimethylamino tetracycline compound (eg, of Formula I, II, III, IV, V, VI, VII, VIII or Table 2). Development and preliminary validation of a pain measure specific to neuropathic pain; The Neuropathic Pain Scale.

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