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Pharmacologically, the TCAs noted for their sleep-enhancing effects are more potent in blocking the serotonin transporter than the norepinephrine transporter, in addition to exerting prominent blockade of histamine H 1 receptors. Such isomers can be obtained in substantially pure form by classical separation techniques and by stereochemically controlled synthesis. Additionally, there was a significantly higher number of patients who discontinued therapy due to adverse reactions, including hypotensive symptoms (48% vs.

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